ChemicalBook > CAS DataBase List > 7,10-Dimethoxy-10-DAB III

7,10-Dimethoxy-10-DAB III

Product Name
7,10-Dimethoxy-10-DAB III
CAS No.
183133-94-0
Chemical Name
7,10-Dimethoxy-10-DAB III
Synonyms
11S;12a;12S;(2aR;4]benz[1;11-dihydroxy-4;6-dimethoxy-4a;7,10-MeO-10-DAB;13-tetramethyl-7;Cabazitaxel IMP
CBNumber
CB42630016
Molecular Formula
C31H40O10
Formula Weight
572.64
MOL File
183133-94-0.mol
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7,10-Dimethoxy-10-DAB III Property

Melting point:
>225°C (dec.)
Boiling point:
675.8±55.0 °C(Predicted)
Density 
1.31
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMF (Slightly, Heated, Sonicated), DMSO (Very Slightly, Heated), Methanol
pka
12.82±0.70(Predicted)
form 
Solid
color 
White to Off-White
Stability:
Hygroscopic
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Safety

HS Code 
29329990
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
D198890
Product name
10-Deacetyl-7,10-dimethoxy-BaccatinIII
Packaging
100mg
Price
$355
Updated
2021/12/16
Usbiological
Product number
411612
Product name
10-Deacetyl-7,10-dimethoxy-Baccatin III
Packaging
50mg
Price
$460
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD31033
Product name
7,10-Dimethoxy-10-DAB III)
Packaging
250mg
Price
$450
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD31033
Product name
7,10-Dimethoxy-10-DAB III)
Packaging
5G
Price
$1575
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD31033
Product name
7,10-Dimethoxy-10-DAB III)
Packaging
10g
Price
$2625
Updated
2021/12/16
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7,10-Dimethoxy-10-DAB III Chemical Properties,Usage,Production

Description

Cabazitaxel is a kind of Second line Drug for the treatment of prostate cancer, FDA Priority Review status approval listing is obtained because its curative effect is remarkable, for the advanced prostate cancer patients to the invalid even aggravation of Docetaxel, the first-selected medicine being used for the treatment of late period, hormone antagonist type prostate cancer.7,10-dimethoxy-10-Dab III is the important intermediate preparing Cabazitaxel.

Uses

4-Deacetyl-4-propionyl Cabazitaxel is an impurity of Cabazitaxel (C046500).A novel semi-synthetic taxane with antitumor activity used for the treatment of castration-resistant prostate cancer. A microtubule inhibitor.

Synthesis

Solvent is methylene dichloride, and alkali is the two dimethylamino naphthalene of 1,8-, and the mol ratio of 10-deacetylate Bakating III and trimethylammonium oxygen Tetrafluoroboric acid is 1:35; The mol ratio of 10-deacetylate Bakating III and alkali is 1:45;By 10-Dab (10g, 18.4mmol) be dissolved in methylene dichloride (200ml), add 1, the two dimethylamino naphthalene (177.2g of 8-, 828mmol), stirring at room temperature half an hour, add trimethylammonium oxygen Tetrafluoroboric acid (95.2g, 643.4mmol) again, stirring at room temperature 20h, suction filtration reaction solution, filter cake methylene dichloride washes 3 times, collects filtrate, and after concentrated, column chromatography (chloroform: methyl alcohol=100:3) obtains 7,10-dimethoxy-10Dab III 4.6g, yield 43.7%.

7,10-Dimethoxy-10-DAB III Preparation Products And Raw materials

Raw materials

Preparation Products

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7,10-Dimethoxy-10-DAB III Suppliers

China 175 China Hong Kong 1 India 6 United Kingdom 2 United States 7 Global 191
Xunteng International Trading Co.,Limited
Tel
Country
China Hong Kong
ProdList
878
Advantage
55
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View Lastest Price from 7,10-Dimethoxy-10-DAB III manufacturers

Hebei Senko Biotechnology Co., Ltd.
Product
7,10-Dimethoxy-10-DAB III 183133-94-0
Price
US $80.00/KG/Tin
Min. Order
1KG
Purity
99%
Supply Ability
10Tons
Release date
2021-07-20
Zhuozhou Wenxi import and Export Co., Ltd
Product
7.10-Dimethoxy-10-DAB III 183133-94-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
7.10-Dimethoxy-10-DAB III 183133-94-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

183133-94-0, 7,10-Dimethoxy-10-DAB IIIRelated Search:

Dapoxetine 7,10-Bis-O-(2,2,2-trichloroethoxycarbonyl)-10-deacetylbaccatin III (4S,5R)-3-tert-butoxycarbony-2-(4-anisy)-4-phenyl-5-oxazolidinecarboxylic acid "7-(triMethylsilyl)-13-O-[((4S,5R)-2,4-diphenyl-4,5-dihydro oxazol-5-yl)carbonyl]baccatin Ⅲ 7-Troc-paclitaxel Cabazitaxel N-3 7-{[(2,2,2,-TRICHLOROETHYL)OXY]CARBONYL} BACCATIN III 2',3'-O,N-[(S)-(p-Methoxybenzylidene)]-7-O-(triethylsilyl)paclitaxel Deacetyltaxol 7-O-(TRIETHYLSILYL) BACCATIN III (4S,5R)-2,4-diphenyl-4,5-dihydrooxazole-5-carboxylic acid Cabazitaxel Docetaxel intermediate 10-Deacetylbaccatin III Paclitaxel Cabazitaxel N-1 (4S,5R)-3-Benzoyl-2-(4-methoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid Docetaxel

  • 7β,10β-diMethoxy-10-deacetylbaccatin III
  • Cabazitaxel interMediate 1
  • 7,10-MeO-10-DAB
  • 7β,10β-Dimethoxy-10-dabⅢ
  • 7β,10β-diMethoxy-10-DAB-II
  • (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4,6-diMethoxy-4a,8,13,13-tetraMethyl-7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxe
  • 7,1-DiMethoxy-1-DAB III
  • (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-oneChemicalBook
  • (2aR
  • 11-dihydroxy-4
  • 11-methano-5H-cyclodeca[3
  • 11S
  • 12a
  • 12b-dodecahydro-9
  • 12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1
  • 12S
  • 13-tetramethyl-7
  • 2-b]oxet-5-oneChemicalBook
  • 4]benz[1
  • 6-dimethoxy-4a
  • 2α,3ξ,5β,7β,10β,13α)-4-Acetoxy-1,13-dihydroxy-7,10-diMethoxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
  • (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9,11-dihydroxy-4,6-diMethoxy-4a,8,13,13-tetraMethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-Methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate
  • Cabazitaxel Impurity
  • 7,10-Dimethoxy-10-DAB III (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one
  • 4-Deacetyl-4-propionyl Cabazitaxel
  • Cabazitaxel Impurity 17
  • (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one
  • 7,10-Dimethoxy-10-DAB III
  • (2aR,4S,4aS,6R,9S,11S,12S,12
  • 10-Deacetyl-7,10-dimethoxy-Baccatin III
  • Cabazitaxel intermediate
  • Cabazitaxel IMP
  • Cabazitaxel Deacyl Impurity
  • Cabazitaxel Initiator 1 impurity A
  • (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12
  • 7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one, 12b-(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-
  • Cabazitaxel lmpurities
  • 4,6-Dimethoxy Baccatin III
  • 7β,10β-dimethoxy-10-DAB-III
  • (2α,3ξ,5β,7β,10β,13α)-4-Acetoxy-1,13-dihydroxy-7,10-di...
  • 183133-94-0 7, 10-Dimethoxy-10-DAB III
  • 7,10-dimethoxy -10-DAB
  • 7,10-dimethoxy-Baccatin III
  • 10-Dimethoxy-10-DAB III
  • 7β,10β-diMethoxy-10-deacetylbaccatin III
  • (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-acetyloxy-1,15-dihydroxy-9,12-dimethoxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate
  • 183133-94-0
  • API
  • Intermediates
  • 183133-94-0